Pramlintide Acetate CAS: 196078-30-5 Ibikoresho bitangwa

Pramlintide (Symlin) ni umuti mushya utera inshinge za diyabete (ubwoko bwa 1 na 2), wakozwe na Amylin Pharmaceuticals (ubu ni ishami ryuzuye rya AstraZeneca) Pramlintide igurishwa nkumunyu wa acetate.

Pramlintide ni analogue ya amylin, imisemburo mito ya peptide isohoka mumaraso na β-selile ya pancreas hamwe na insuline, nyuma yo kurya.Nkuko insuline, amylin idahari rwose kubantu barwaye diyabete yo mu bwoko bwa I.

Kugabanuka kwa glycated hemoglobine no kugabanya ibiro byagaragaye ku barwayi bavuwe na insuline barwaye diyabete yo mu bwoko bwa 2 bafata pramlintide nk'ubuvuzi bufatika.

Mu kongera amyline ya endogenous, pramlintide ifasha mukwinjira kwa selile no kugenzura glucose yamaraso mugutinda gusiba gastrica, guteza imbere guhaga hifashishijwe reseptor ya hypothalamic (reseptors zitandukanye kuruta GLP-1), no kubuza gusohora bidakwiye glucagon, imisemburo ya catabolika irwanya ingaruka ya insuline na amylin.Pramlintide igira kandi ingaruka mukuzamura icyiciro cya mbere cya insuline yo gusubiza nyuma yo kurya.